PIPELINE
Pipeline details
[IL2102] SOS1 Inhibitor for RAS Driven Cancers
[IL2102] SOS1 Inhibitor for RAS Driven Cancers • Potentially best-in-class, orally available, small molecule SOS1 inhibitor for any RAS driven cancers which has shown strong activity against various KRAS mutants and wild types including KRAS G12C, G12D, G12V and KRAS G13C. • SOS1 is a pivotal switch that converts RAS from its inactive (off) state to its active (on) state, representing a novel therapeutic target in RAS-driven cancers Inhibition of the GTP exchange…
[IL2106] Cyclin-K Degrader for Solid Tumors
[IL2106] Cyclin-K Degrader for Solid Tumors • Potentially first-in-class, orally available, small molecule Cyclin-K Degrader with strong anti-cancer activities for difficult cancers including those without identifiable drivers. • We are developing a potent Cyclin-K Degrader (through CDK 12 binding) which can be used for cancers without known drivers including HER2-negative gastric cancer, HER2-negative TNBC, colorectal cancer, etc. • The lead candidate acts as a …
[IL2112] CXCR 7 Agonist for Neurodegenerative Diseases
[IL2112] CXCR 7 Agonist for Neurodegenerative Diseases • Potentially first-in-class, orally available, small molecule CXCR7 agonist with a high permeability for the blood–brain barrier (BBB) for various neurodegenerative diseases such as ALS, Multiple sclerosis (MS), Parkinson’s Disease (PD), etc.• Brain injury triggers the accumulation of microglia via the CXCL12/CXCR4 pathway, while concurrently inducing the attenuation of the CXCR7/PI3K/Akt signaling cascade in …
[IL2112] CXCR 7 Agonist for Fibrotic Diseases
[IL2112] CXCR 7 Agonist for Fibrotic Diseases • First-in-class, orally available, small molecule, chemokine receptor type 7 (CXCR7) agonist for treatment of various fibrotic and autoimmune diseases.• Chemokines play crucial roles in many physiological and pathological processes. Chemokine receptor 7 (CXCR7) is a receptor that binds to CXCL12, a known pro-inflammatory factor under pathological conditions such as inflammation, hypoxia, tumor, autoimmune disease and it ac…